DegronMD

Uniprot ID: Q92953

Source protein: Potassium voltage-gated channel subfamily B member 2

Source gene: KCNB2

Class: DEG_APCC_KENBOX_2

Location: 719:723

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.514

ASA_SCORE: 111.56

COIL: 0.7806

CONS_SCORE: 0.2903

DSS_SCORE: 0.708

HELIX: 0.048

FCONS_SCORE: 0.9547

RIG_SCORE: 0.6453

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S712F	TCGA-18-3409	LUSC	TCGA	FKENR	DEG_APCC_KENBOX_2	0.1389
p.S712F	DO26444	LUSC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1389
p.S712T	TCGA-AZ-4315	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	0.1389
p.S712T	DO8842	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1389
p.A726V	TCGA-CK-5916	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	0.25
p.A726V	DO8786	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	0.25
p.E721K	TCGA-D3-A2JL	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	TCGA-EB-A3Y7	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	TCGA-EB-A6QZ	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	TCGA-ER-A19M	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO222363	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO222837	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO219879	SKCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO47278	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO37798	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO37499	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	DO48626	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	SIDM00568	Gastric Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	ACH-000247	Gastric Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	ACH-000553	Lung Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	ACH-000813	Lung Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E721K	OCUM-1	stomach	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.R723G	DO233818	GACA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.6457
p.K720M	DO231722	LINC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.8062
p.G724A	SIDM00845	Burkitt's Lymphoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.3056
p.S714F	SIDM00974	Melanoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.6389
p.S714F	WM35	skin	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_APCC_KENBOX_2	1406:1410	FKENR	APC,CDC20,FZR1	0.8816	More...
Q12955	Ankyrin-3	DEG_APCC_KENBOX_2	1390:1394	FKENR	APC,CDC20,FZR1	0.9806	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_APCC_KENBOX_2	817:821	FKENR	APC,CDC20,FZR1	0.5975	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_APCC_KENBOX_2	719:723	FKENR	APC,CDC20,FZR1	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FKENR

Degron related mutations and impact score

Drug responses associated with KCNB2 mutations

All proteins holding degron of FKENR