DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_APCC_KENBOX_2

Location: 1390:1394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9806

ASA_SCORE: 80.32

COIL: 0.7244

CONS_SCORE: 0.6779

DSS_SCORE: 0.0826

HELIX: 0.0784

FCONS_SCORE: 1.23

RIG_SCORE: 0.8479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1387C	TCGA-AJ-A5DW	UCEC	TCGA	FKENR	DEG_APCC_KENBOX_2	0.25
p.R1394K	TCGA-FW-A3R5	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.6126
p.F1391L	DO228745	EOPC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.6981
p.G1380R	DO232761	PBCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.G1380R	DO229459	SKCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.R1395K	DO37406	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.3056
p.F1388C	DO50075	UCEC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_APCC_KENBOX_2	1406:1410	FKENR	APC,CDC20,FZR1	0.8816	More...
Q12955	Ankyrin-3	DEG_APCC_KENBOX_2	1390:1394	FKENR	APC,CDC20,FZR1	0.9806	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_APCC_KENBOX_2	817:821	FKENR	APC,CDC20,FZR1	0.5975	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_APCC_KENBOX_2	719:723	FKENR	APC,CDC20,FZR1	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons