DegronMD

Uniprot ID: Q66GS9

Source protein: Centrosomal protein of 135 kDa

Source gene: CEP135

Class: DEG_APCC_KENBOX_2

Location: 817:821

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5975

ASA_SCORE: 116.94

COIL: 0.0194

CONS_SCORE: 0.7061

DSS_SCORE: 0.3922

HELIX: 0.9816

FCONS_SCORE: 1.0428

RIG_SCORE: 0.7728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D807N	TCGA-06-5416	GBM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.0556
p.D807N	DO10880	GBM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.D807N	SIDM00149	Melanoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.D807N	ACH-000750	Skin Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	0.0556
p.D807N	LOXIMVI	skin	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.E819K	TCGA-EE-A3J3	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E819K	DO48652	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.Q824R	TCGA-IZ-A6M9	KIRP	TCGA	FKENR	DEG_APCC_KENBOX_2	0.25
p.Q824R	DO44501	KIRP	ICGC	FKENR	DEG_APCC_KENBOX_2	0.25
p.G810R	DO222696	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_APCC_KENBOX_2	1406:1410	FKENR	APC,CDC20,FZR1	0.8816	More...
Q12955	Ankyrin-3	DEG_APCC_KENBOX_2	1390:1394	FKENR	APC,CDC20,FZR1	0.9806	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_APCC_KENBOX_2	817:821	FKENR	APC,CDC20,FZR1	0.5975	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_APCC_KENBOX_2	719:723	FKENR	APC,CDC20,FZR1	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons