DegronMD - Q66GS9(CEP135)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D807N	TCGA-06-5416	GBM	TCGA	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.0556
p.D807N	DO10880	GBM	ICGC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.0556
p.D807N	SIDM00149	Melanoma	GDSC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.0556
p.D807N	ACH-000750	Skin Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.0556
p.D807N	LOXIMVI	skin	COSMIC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.0556
p.M1114L	TCGA-51-4081	LUSC	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1944
p.M1114L	TCGA-51-4081	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.M1114L	DO26544	LUSC	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1944
p.M1114L	DO26544	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.E1113A	TCGA-A3-3357	KIRC	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1667
p.E1113A	TCGA-A3-3357	KIRC	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0556
p.E1113A	DO20396	KIRC	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1667
p.E1113A	DO20396	KIRC	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0556
p.R1115C	TCGA-A6-2686	COAD	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.2222
p.R1115C	TCGA-A6-2686	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.R1115C	DO7828	COAD	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.2222
p.R1115C	DO7828	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.R1115C	DO228138	PBCA	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.2222
p.R1115C	DO228138	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.S1130F	TCGA-BF-A3DL	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation blocking phosphorylation signal	0.6389
p.S1130F	TCGA-BF-A3DL	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation blocking phosphorylation signal	0.6944
p.S1130F	DO51238	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation blocking phosphorylation signal	0.6389
p.S1130F	DO51238	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation blocking phosphorylation signal	0.6944
p.S1134Y	TCGA-DF-A2KN	UCEC	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation blocking phosphorylation signal	0.5278
p.S1134Y	TCGA-DF-A2KN	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation blocking phosphorylation signal	0.5833
p.S1134Y	DO223282	UCEC	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation blocking phosphorylation signal	0.5278
p.S1134Y	DO223282	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation blocking phosphorylation signal	0.5833
p.E819K	TCGA-EE-A3J3	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation altering degron motif	0.7022
p.E819K	DO48652	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation altering degron motif	0.7022
p.R1109Q	TCGA-GF-A3OT	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.0556
p.R1109Q	DO47288	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.0556
p.Q824R	TCGA-IZ-A6M9	KIRP	TCGA	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.25
p.Q824R	DO44501	KIRP	ICGC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.25
p.P1131S	TCGA-OD-A75X	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1667
p.P1131S	TCGA-OD-A75X	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2222
p.P1131S	DO48601	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.1667
p.P1131S	DO48601	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2222
p.R1115L	DO231939	LICA	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.2222
p.R1115L	DO231939	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.A1110S	DO229006	LICA	ICGC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.0833
p.G810R	DO222696	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	817:821	Mutation rewiring degron network	0.1389
p.S1125R	SIDM00699	Small Cell Lung Carcinoma	GDSC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation altering degron motif	0.7427
p.S1125R	SIDM00699	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7427
p.S1125R	ACH-001138	Lung Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation altering degron motif	0.7427
p.S1125R	ACH-001138	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7427
p.S1125R	NCI-H2141	lung	COSMIC	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation altering degron motif	0.7427
p.S1125R	NCI-H2141	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7427
p.L1119I	ACH-000681	Lung Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation altering degron motif	0.6063
p.R1115H	ACH-001513	Cervical Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	1119:1125	Mutation rewiring degron network	0.2222
p.R1115H	ACH-001513	Cervical Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111

Kaplan plot for CEP135 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP135

UniProt ID: Q66GS9

Entrez ID: 9662

Protein name: Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP135 in