DegronMD

Uniprot ID: Q66GS9

Source protein: Centrosomal protein of 135 kDa

Source gene: CEP135

Class: DEG_SCF_FBW7_1

Location: 1119:1125

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 93.5714

COIL: 0.9151

CONS_SCORE: 0.6502

DSS_SCORE: 0.6859

HELIX: 0.0749

FCONS_SCORE: 1.0397

RIG_SCORE: 0.6148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1114L	TCGA-51-4081	LUSC	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.1944
p.M1114L	DO26544	LUSC	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.1944
p.E1113A	TCGA-A3-3357	KIRC	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.1667
p.E1113A	DO20396	KIRC	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.1667
p.R1115C	TCGA-A6-2686	COAD	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.2222
p.R1115C	DO7828	COAD	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.2222
p.R1115C	DO228138	PBCA	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.2222
p.S1130F	TCGA-BF-A3DL	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.6389
p.S1130F	DO51238	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.6389
p.S1134Y	TCGA-DF-A2KN	UCEC	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.5278
p.S1134Y	DO223282	UCEC	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.5278
p.R1109Q	TCGA-GF-A3OT	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.0556
p.R1109Q	DO47288	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.0556
p.P1131S	TCGA-OD-A75X	SKCM	TCGA	LATPPLS	DEG_SCF_FBW7_1	0.1667
p.P1131S	DO48601	SKCM	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.1667
p.R1115L	DO231939	LICA	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.2222
p.A1110S	DO229006	LICA	ICGC	LATPPLS	DEG_SCF_FBW7_1	0.0833
p.S1125R	SIDM00699	Small Cell Lung Carcinoma	GDSC	LATPPLS	DEG_SCF_FBW7_1	0.7427
p.S1125R	ACH-001138	Lung Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	0.7427
p.S1125R	NCI-H2141	lung	COSMIC	LATPPLS	DEG_SCF_FBW7_1	0.7427
p.L1119I	ACH-000681	Lung Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	0.6063
p.R1115H	ACH-001513	Cervical Cancer	CCLE	LATPPLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66GS9	Centrosomal protein of 135 kDa	DEG_SCF_FBW7_1	1119:1125	LATPPLS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons