DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_1

Location: 1758:1765

E3 ligase: FBXW7

DEGRON score: 0.9828

ASA_SCORE: 81.325

COIL: 0.6861

CONS_SCORE: 0.4503

DSS_SCORE: 0.5047

HELIX: 0.045

FCONS_SCORE: 1.0557

RIG_SCORE: 0.7323

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1763F	TCGA-55-7725	LUAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.6304
p.I1763F	DO24636	LUAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.6304
p.P1749L	TCGA-55-A4DG	LUAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.0833
p.P1749L	DO26337	LUAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.0833
p.E1759K	TCGA-AA-A01P	COAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.591
p.E1759K	DO8642	COAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.591
p.S1755Y	TCGA-BS-A0UF	UCEC	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.6944
p.S1755Y	DO41488	UCEC	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.6944
p.K1769N	TCGA-CG-4437	STAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.3333
p.K1769N	DO38467	STAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.3333
p.P1749T	TCGA-EI-6917	READ	TCGA	IEETPIGS	DEG_SCF_FBW7_1	0.0833
p.P1749T	DO36881	READ	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.0833
p.E1760K	DO48360	BLCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.591
p.K1769E	DO227987	COCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.3333
p.A1772P	DO45299	LIRI	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.1389
p.S1765F	DO229494	SKCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.7982
p.S1765F	SIDM00401	Melanoma	GDSC	IEETPIGS	DEG_SCF_FBW7_1	0.7982
p.S1765F	RVH-421	skin	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.7982
p.L1748F	DO229446	SKCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	0.0556
p.P1762S	SIDM01175	Other Sarcomas	GDSC	IEETPIGS	DEG_SCF_FBW7_1	0.6752
p.P1762S	SW684	soft_tissue	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.6752
p.P1762L	SIDM01175	Other Sarcomas	GDSC	IEETPIGS	DEG_SCF_FBW7_1	0.7582
p.P1762L	SW684	soft_tissue	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.7582
p.D1763E	ACH-000680	Colon/Colorectal Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	0.6758
p.D1763E	SW948	large_intestine	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.6758
p.K1767R	ACH-000847	Gastric Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	0.2778
p.K1767R	HGC-27	stomach	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.2778
p.H1770Y	ACH-000999	Colon/Colorectal Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	0.1944
p.H1770Y	SNU-1040	large_intestine	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.1944
p.K1759I	ACH-002163	Breast Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	0.7531
p.K1759I	MRK-nu-1	breast	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.7531
p.N1769K	H3255	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.3333
p.E1756V	NCI-H23	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.2778
p.N1760K	H3255	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.6918
p.A1758D	H513	pleura	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.7793
p.A1767D	H513	pleura	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.2778
p.E1765V	NCI-H23	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	0.7693

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IEETPIGS

Degron related mutations and impact score

Drug responses associated with ANK2 mutations

All proteins holding degron of IEETPIGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_1	1758:1765	IEETPIGS	FBXW7	0.9828	More...