DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_2

Location: 3774:3780

E3 ligase: FBXW7

DEGRON score: 0.8567

ASA_SCORE: 86.1571

COIL: 0.8336

CONS_SCORE: 0.3986

DSS_SCORE: 0.5918

HELIX: 0.0206

FCONS_SCORE: 1.0639

RIG_SCORE: 0.6883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3783D	TCGA-AP-A056	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	0.25
p.E3783D	DO43971	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	0.25
p.Q3770H	TCGA-B5-A11E	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	0.2222
p.Q3770H	DO41644	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	0.2222
p.E3780K	TCGA-D9-A6EC	SKCM	TCGA	VTTPGTE	DEG_SCF_FBW7_2	0.7022
p.E3780K	DO50291	SKCM	ICGC	VTTPGTE	DEG_SCF_FBW7_2	0.7022
p.A3787V	TCGA-EO-A22U	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	0.1389
p.A3787V	DO43755	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	0.1389
p.T3779I	DO220902	MELA	ICGC	VTTPGTE	DEG_SCF_FBW7_2	0.5966
p.K3786E	SIDM00617	Hepatocellular Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.2778
p.K3786E	JHH-2	liver	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	0.2778
p.Q3785R	SIDM00060	Ovarian Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.1944
p.V3774M	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.V3774M	SIDM00613	Glioblastoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.V3774M	SIDM00160	Biliary Tract Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.V3774M	SIDM01321	Pancreatic Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.V3774M	KALS-1	central_nervous_system	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.V3774M	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	0.6097
p.E3766Q	ACH-000490	Cervical Cancer	CCLE	VTTPGTE	DEG_SCF_FBW7_2	0.1111
p.G3788E	ACH-000759	Breast Cancer	CCLE	VTTPGTE	DEG_SCF_FBW7_2	0.1111
p.G3788E	MDA-MB-175-VII	breast	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_2	3774:3780	VTTPGTE	FBXW7	0.8567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons