DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_1

Location: 2550:2555

E3 ligase: FBXW7

DEGRON score: 0.9296

ASA_SCORE: 92.6833

COIL: 0.8797

CONS_SCORE: 0.4265

DSS_SCORE: 0.6278

HELIX: 0.0218

FCONS_SCORE: 1.0677

RIG_SCORE: 0.6752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2563V	TCGA-AA-3510	COAD	TCGA	VTPKTT	DEG_SCF_FBW7_1	0.1111
p.A2563V	DO7783	COAD	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.1111
p.T2555I	TCGA-BR-8081	STAD	TCGA	VTPKTT	DEG_SCF_FBW7_1	0.7078
p.T2555I	DO38795	STAD	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.7078
p.P2552H	TCGA-EE-A2MK	SKCM	TCGA	VTPKTT	DEG_SCF_FBW7_1	0.7694
p.P2552H	DO38177	SKCM	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.7694
p.P2560T	DO228740	GACA	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.1944
p.S2542I	DO229018	LICA	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.1111
p.V2564L	DO229019	LICA	ICGC	VTPKTT	DEG_SCF_FBW7_1	0.0833
p.N2543K	ACH-000627	Lung Cancer	CCLE	VTPKTT	DEG_SCF_FBW7_1	0.1389
p.N2543K	LCLC-103H	lung	COSMIC	VTPKTT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_1	2550:2555	VTPKTT	FBXW7	0.9296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons