DegronMD - Q9Y493(ZAN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P664L	TCGA-44-8119	LUAD	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation altering degron motif	0.7582
p.P664L	DO24399	LUAD	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation altering degron motif	0.7582
p.V538L	TCGA-68-8250	LUSC	TCGA	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.V538L	DO26993	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.P675H	TCGA-AZ-6601	COAD	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1111
p.P675H	DO8119	COAD	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1111
p.E806K	TCGA-BA-5152	HNSC	TCGA	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation altering degron motif	0.591
p.E806K	DO14393	HNSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation altering degron motif	0.591
p.P657T	TCGA-D1-A1O7	UCEC	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.P657T	DO41139	UCEC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.P547S	TCGA-D3-A5GO	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.6752
p.P547S	DO47419	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.6752
p.P540T	TCGA-EO-A3AY	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.P540T	DO43202	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.E561K	TCGA-F5-6814	READ	TCGA	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0556
p.E561K	DO36556	READ	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0556
p.P657L	TCGA-FR-A726	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.P657L	DO48665	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.S671T	TCGA-FW-A3R5	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.S671T	DO37406	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.T551N	TCGA-ND-A4WC	UCS	TCGA	PVSST	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7055
p.E674Q	TCGA-S5-A6DX	BLCA	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1389
p.E674Q	DO51903	BLCA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1389
p.V656I	TCGA-SX-A7SS	KIRP	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.V656I	DO49794	KIRP	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.V656I	DO229052	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.V656I	DO229058	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.V656I	DO229061	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.V656I	DO229060	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.E659K	TCGA-Z2-A8RT	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2778
p.E659K	DO220891	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2778
p.E659K	DO51301	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2778
p.P543H	DO233115	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.V656F	DO229036	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.1944
p.I796V	DO224589	LUSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation rewiring degron network	0.1944
p.T670A	DO26459	LUSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.25
p.S671F	DO220879	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.P657S	DO222868	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	661:667	Mutation rewiring degron network	0.2222
p.G558N	DO222843	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.V545I	DO48935	PBCA	ICGC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.V545I	SIDM01157	Other Solid Cancers	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.S549F	SIDM00545	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7982
p.T808A	SIDM00607	Glioblastoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation rewiring degron network	0.3056
p.T808A	SIDM00083	Glioblastoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation rewiring degron network	0.3056
p.S554C	SIDM00963	Breast Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.V548I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.5965
p.E800D	SIDM00887	Other Solid Cancers	GDSC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation rewiring degron network	0.3056
p.P543S	SIDM00140	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.P553L	SIDM00140	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.E799D	SIDM01588	Endometrial Carcinoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	801:807	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZAN

UniProt ID: Q9Y493

Entrez ID: 7455

Protein name: Zonadhesin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZAN in