DegronMD

Uniprot ID: Q9Y493

Source protein: Zonadhesin

Source gene: ZAN

Class: DEG_SCF_FBW7_2

Location: 661:667

E3 ligase: FBXW7

DEGRON score: 0.8787

ASA_SCORE: 105.5571

COIL: 0.946

CONS_SCORE: 0.3664

DSS_SCORE: 0.8535

HELIX: 0.0191

FCONS_SCORE: 0.9628

RIG_SCORE: 0.6188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P664L	TCGA-44-8119	LUAD	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.7582
p.P664L	DO24399	LUAD	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.7582
p.P675H	TCGA-AZ-6601	COAD	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.1111
p.P675H	DO8119	COAD	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1111
p.P657T	TCGA-D1-A1O7	UCEC	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.P657T	DO41139	UCEC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.P657L	TCGA-FR-A726	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.P657L	DO48665	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.S671T	TCGA-FW-A3R5	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.S671T	DO37406	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.E674Q	TCGA-S5-A6DX	BLCA	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.1389
p.E674Q	DO51903	BLCA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1389
p.V656I	TCGA-SX-A7SS	KIRP	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.V656I	DO49794	KIRP	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.V656I	DO229052	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.V656I	DO229058	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.V656I	DO229061	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.V656I	DO229060	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.E659K	TCGA-Z2-A8RT	SKCM	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.2778
p.E659K	DO220891	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2778
p.E659K	DO51301	SKCM	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2778
p.V656F	DO229036	LICA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.T670A	DO26459	LUSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.25
p.S671F	DO220879	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2222
p.P657S	DO222868	MELA	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons