DegronMD

Uniprot ID: Q9Y493

Source protein: Zonadhesin

Source gene: ZAN

Class: DEG_SCF_FBW7_2

Location: 801:807

E3 ligase: FBXW7

DEGRON score: 0.9237

ASA_SCORE: 98.8571

COIL: 0.9209

CONS_SCORE: 0.3718

DSS_SCORE: 0.8258

HELIX: 0.0213

FCONS_SCORE: 1.0595

RIG_SCORE: 0.6323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E806K	TCGA-BA-5152	HNSC	TCGA	PTTPTEE	DEG_SCF_FBW7_2	0.591
p.E806K	DO14393	HNSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.591
p.I796V	DO224589	LUSC	ICGC	PTTPTEE	DEG_SCF_FBW7_2	0.1944
p.T808A	SIDM00607	Glioblastoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	0.3056
p.T808A	SIDM00083	Glioblastoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	0.3056
p.E800D	SIDM00887	Other Solid Cancers	GDSC	PTTPTEE	DEG_SCF_FBW7_2	0.3056
p.E799D	SIDM01588	Endometrial Carcinoma	GDSC	PTTPTEE	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons