DegronMD - Q96LX7(CCDC17)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q78R	TCGA-BG-A222	UCEC	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.Q78R	DO42977	UCEC	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.S82F	TCGA-CK-5915	COAD	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6871
p.S82F	DO7862	COAD	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6871
p.T583I	TCGA-CM-5860	COAD	TCGA	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0833
p.A579D	TCGA-DX-A6YV	SARC	TCGA	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1944
p.W93R	TCGA-G4-6304	COAD	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1944
p.W93R	DO10639	COAD	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1944
p.T574I	DO10542	COAD	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7078
p.S571N	DO230334	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO229010	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO229013	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO229016	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO229003	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO229005	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S571N	DO228947	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7069
p.S566F	DO222441	ESCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.P582T	DO228971	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1111
p.P582T	DO43306	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1111
p.A576T	DO232826	NACA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2778
p.A576T	DO51154	PRAD	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2778
p.A570D	DO220011	SARC	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7793
p.S571I	DO229248	THCA	ICGC	PVSST	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7341
p.V90A	GP5d	large intestine	COSMIC	SRSALKRLT	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC17

UniProt ID: Q96LX7

Entrez ID: 149483

Protein name: Coiled-coil domain-containing protein 17

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC17 in