DegronMD

Uniprot ID: Q96LX7

Source protein: Coiled-coil domain-containing protein 17

Source gene: CCDC17

Class: DEG_APCC_DBOX_1

Location: 80:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8535

ASA_SCORE: 89.1111

COIL: 0.2033

CONS_SCORE: 0.4654

DSS_SCORE: 0.4321

HELIX: 0.8013

FCONS_SCORE: 1.5063

RIG_SCORE: 0.7399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q78R	TCGA-BG-A222	UCEC	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	0.2778
p.Q78R	DO42977	UCEC	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	0.2778
p.S82F	TCGA-CK-5915	COAD	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	0.6871
p.S82F	DO7862	COAD	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	0.6871
p.W93R	TCGA-G4-6304	COAD	TCGA	SRSALKRLT	DEG_APCC_DBOX_1	0.1944
p.W93R	DO10639	COAD	ICGC	SRSALKRLT	DEG_APCC_DBOX_1	0.1944
p.V90A	GP5d	large_intestine	COSMIC	SRSALKRLT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LX7	Coiled-coil domain-containing protein 17	DEG_APCC_DBOX_1	80:88	SRSALKRLT	APC,CDC20,FZR1	0.8535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons