DegronMD

Uniprot ID: Q96RK0

Source protein: Protein capicua homolog

Source gene: CIC

Class: DEG_SPOP_SBC_1

Location: 1101:1105

E3 ligase: SPOP

DEGRON score: 0.9863

ASA_SCORE: 79.46

COIL: 0.949

CONS_SCORE: 0.3529

DSS_SCORE: 0.465

HELIX: 0.022

FCONS_SCORE: 0.9178

RIG_SCORE: 0.6138

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1095V	TCGA-D7-A6EY	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.F1095V	DO50118	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.S1104F	TCGA-EE-A181	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	0.7982
p.N1102Y	DO51866	BLCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7059
p.E1095Q	DO456	BLCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.S1103T	DO228483	BRCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7116
p.S1103T	DO229005	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7116
p.R1110W	DO50210	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1110W	DO50188	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1110W	DO22634	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1110W	DO22199	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1110W	DO223674	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1110W	DO223698	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R1111W	DO50196	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R1111W	DO50252	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R1111W	DO22235	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R1111W	DO223690	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R1111W	DO223696	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.P1112L	DO50177	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1389
p.P1112S	DO50146	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1389
p.P1112S	DO22109	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1389
p.N1114S	DO22443	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.0833
p.R1111Q	DO44595	LGG	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.S1094F	DO229446	SKCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.1389
p.S1103F	DO37444	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	0.7982
p.R1099C	DO41823	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.2778
p.R1099C	ACH-000398	Lymphoma	CCLE	APTSS	DEG_SPOP_SBC_1	0.2778
p.G1098E	DO41361	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.S1104T	SIDM00615	Hepatocellular Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM00060	Ovarian Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM00618	Hepatocellular Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM00603	Head and Neck Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM01611	Endometrial Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1104T	SIDM01690	Plasma Cell Myeloma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6005
p.S1097P	SIDM00845	Burkitt's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.2222
p.S1097P	SIDM01519	Head and Neck Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.2222
p.P1102L	SIDM00217	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6471
p.N1114D	ACH-000990	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.0833
p.N1102D	ACH-000998	Colon/Colorectal Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.6932
p.N1102D	CW-2	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.6932
p.R1104Q	NCI-SNU-16	stomach	COSMIC	APTSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	934:938	APTSS	SPOP	0.9885	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	325:329	APTSS	SPOP	0.9804	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
O60268	Uncharacterized protein KIAA0513	DEG_SPOP_SBC_1	18:22	APTSS	SPOP	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with CIC mutations

All proteins holding degron of APTSS