DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
KIAA0513
UniProt ID:
O60268
Entrez ID:
9764
Protein name:
Uncharacterized protein KIAA0513
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
cytoplasm [GO:0005737]...
cytoplasm [GO:0005737]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
KIAA0513
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CCLE
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Show Degron:
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Phosphorylation
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.P23L
TCGA-18-3409
LUSC
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.3056
p.P23L
DO26444
LUSC
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.3056
p.Q32K
TCGA-25-2396
OV
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.Q32K
TCGA-25-2399
OV
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.Q32K
TCGA-AB-2867
LAML
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.Q32K
DO22062
LAML
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.Q32K
DO29206
OV
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.Q32K
DO31280
OV
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.P23S
TCGA-EE-A2GC
SKCM
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.3056
p.P23S
DO37839
SKCM
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.3056
p.V8M
TCGA-EO-A22U
UCEC
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.V8M
DO43755
UCEC
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.0556
p.A18V
TCGA-PE-A5DD
BRCA
TCGA
APTSS
DEG_SPOP_SBC_1
18:22
Mutation altering degron motif
0.5825
p.A18V
DO219642
BRCA
ICGC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation altering degron motif
0.5825
p.P29S
SIDM00923
Cervical Carcinoma
GDSC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.1389
p.P29S
ACH-001336
Cervical Cancer
CCLE
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.1389
p.P29S
Ca-Ski
cervix
COSMIC
APTSS
DEG_SPOP_SBC_1
18:22
Mutation rewiring degron network
0.1389
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for KIAA0513 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc