DegronMD

Uniprot ID: O60268

Source protein: Uncharacterized protein KIAA0513

Source gene: KIAA0513

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.9546

ASA_SCORE: 75.44

COIL: 0.967

CONS_SCORE: 0.5947

DSS_SCORE: 0.7497

HELIX: 0.023

FCONS_SCORE: 0.929

RIG_SCORE: 0.6109

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A18V	TCGA-PE-A5DD	BRCA	TCGA	APTSS	DEG_SPOP_SBC_1	0.5825
p.A18V	DO219642	BRCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.5825
p.P23L	TCGA-18-3409	LUSC	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.P23L	DO26444	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.P23S	TCGA-EE-A2GC	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.P23S	DO37839	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.P29S	SIDM00923	Cervical Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.1389
p.P29S	ACH-001336	Cervical Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.1389
p.P29S	Ca-Ski	cervix	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1389
p.Q32K	TCGA-25-2396	OV	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.Q32K	TCGA-25-2399	OV	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.Q32K	TCGA-AB-2867	LAML	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.Q32K	DO22062	LAML	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.Q32K	DO29206	OV	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.Q32K	DO31280	OV	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.V8M	TCGA-EO-A22U	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.V8M	DO43755	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 17 of 17 entries

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Drug responses associated with KIAA0513 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with KIAA0513 mutations

All proteins holding degron of APTSS