DegronMD - Q9BRQ6(CHCHD6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R37H	TCGA-2W-A8YY	CESC	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.R37H	DO223732	CESC	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.R37H	SIDM01174	Cervical Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.R37H	ACH-001402	Cervical Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.R37H	SW756	cervix	COSMIC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.T52A	TCGA-60-2704	LUSC	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.T52A	DO26555	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.R37L	TCGA-86-A4JF	LUAD	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.R37L	DO45317	LUAD	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556
p.P41L	TCGA-DD-A118	LIHC	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.P41L	DO22905	LIHC	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.S42I	TCGA-DX-A6YT	SARC	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation blocking phosphorylation signal	0.6389
p.S42I	DO220007	SARC	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation blocking phosphorylation signal	0.6389
p.D57Y	TCGA-E6-A1M0	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.D57Y	DO43682	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.A47S	DO229019	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.7588
p.G58D	SIDM00334	Endometrial Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.G58D	ACH-000879	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.G58D	MFE-296	endometrium	COSMIC	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.R61K	ACH-000025	Brain Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0556

Kaplan plot for CHCHD6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHCHD6

UniProt ID: Q9BRQ6

Entrez ID: 84303

Protein name: MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHCHD6 in