DegronMD

Uniprot ID: Q9BRQ6

Source protein: MICOS complex subunit MIC25

Source gene: CHCHD6

Class: DEG_SPOP_SBC_1

Location: 47:51

E3 ligase: SPOP

DEGRON score: 0.8935

ASA_SCORE: 73.06

COIL: 0.907

CONS_SCORE: 0.4645

DSS_SCORE: 0.7932

HELIX: 0.056

FCONS_SCORE: 0.9176

RIG_SCORE: 0.5769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R37H	TCGA-2W-A8YY	CESC	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.R37H	DO223732	CESC	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.R37H	SIDM01174	Cervical Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.0556
p.R37H	ACH-001402	Cervical Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.0556
p.R37H	SW756	cervix	COSMIC	APTSS	DEG_SPOP_SBC_1	0.0556
p.T52A	TCGA-60-2704	LUSC	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.T52A	DO26555	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.R37L	TCGA-86-A4JF	LUAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.0556
p.R37L	DO45317	LUAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.P41L	TCGA-DD-A118	LIHC	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.P41L	DO22905	LIHC	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.S42I	TCGA-DX-A6YT	SARC	TCGA	APTSS	DEG_SPOP_SBC_1	0.6389
p.S42I	DO220007	SARC	ICGC	APTSS	DEG_SPOP_SBC_1	0.6389
p.D57Y	TCGA-E6-A1M0	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.D57Y	DO43682	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.A47S	DO229019	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7588
p.G58D	SIDM00334	Endometrial Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.1389
p.G58D	ACH-000879	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.1389
p.G58D	MFE-296	endometrium	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1389
p.R61K	ACH-000025	Brain Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	934:938	APTSS	SPOP	0.9885	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	325:329	APTSS	SPOP	0.9804	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
O60268	Uncharacterized protein KIAA0513	DEG_SPOP_SBC_1	18:22	APTSS	SPOP	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with CHCHD6 mutations

All proteins holding degron of APTSS