DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 44:48

E3 ligase: SPOP

DEGRON score: 0.7194

ASA_SCORE: 72.4

COIL: 0.937

CONS_SCORE: 0.241

DSS_SCORE: 0.6396

HELIX: 0.0116

FCONS_SCORE: 0.7783

RIG_SCORE: 0.5753

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S48L	DO222625	BTCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.8778
p.S47Y	SIDM00730	Small Cell Lung Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.8231
p.S47Y	ACH-000610	Lung Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.8231
p.A44S	DO229018	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7588
p.A44S	DO229035	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7588
p.T46M	SIDM01086	B-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	0.7423
p.G42S	ACH-000990	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.2778
p.R51Q	TCGA-L5-A8NN	ESCA	TCGA	APTSS	DEG_SPOP_SBC_1	0.25
p.R51Q	TCGA-W5-AA2Z	CHOL	TCGA	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO229010	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO229013	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO229346	LAML	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO52365	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO231022	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.R51W	DO231155	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.D41G	ACH-000964	Leukemia	CCLE	APTSS	DEG_SPOP_SBC_1	0.25
p.R52H	DO222765	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.2222
p.E34G	DO229010	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.E34G	DO229013	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.E34G	DO229346	LAML	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.E34G	DO230659	LAML	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 21 of 21 entries

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Drug responses associated with MUC5B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of APTSS