DegronMD

Uniprot ID: O43432

Source protein: Eukaryotic translation initiation factor 4 gamma 3

Source gene: EIF4G3

Class: DEG_SPOP_SBC_1

Location: 281:285

E3 ligase: SPOP

DEGRON score: 0.9619

ASA_SCORE: 83.86

COIL: 0.9328

CONS_SCORE: 0.2153

DSS_SCORE: 0.3963

HELIX: 0.0372

FCONS_SCORE: 0.9258

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V280A	TCGA-AG-A002	READ	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.P274R	TCGA-AP-A0LF	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.1389
p.P274R	DO43610	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.1389
p.S279F	TCGA-IB-7651	PAAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.2778
p.S279F	DO46657	PAAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.2778
p.D277E	DO229018	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.2222
p.S295R	DO229026	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.P271T	DO229026	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.0556
p.F272L	DO222847	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	0.0833
p.F272L	DO48547	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.0833
p.P288L	DO227740	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.25
p.V284M	DO48946	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7208
p.L281I	DO42033	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.7174
p.A286T	DO41235	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.I278V	SIDM00845	Burkitt's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.25
p.R275Q	SIDM00217	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R275Q	SNU-1040	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1667
p.E289Q	NCI-H1838	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	0.2222
p.R287Q	SNU-1040	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.2778
p.A286V	PL18	pancreas	COSMIC	APTSS	DEG_SPOP_SBC_1	0.3056
p.R282Q	SNU-1040	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.7329
p.E292D	TK	haematopoietic_and_lymphoid_tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1389
p.P291S	TE-441-T	soft_tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1667
p.R276Q	SNU-1040	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	934:938	APTSS	SPOP	0.9885	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	325:329	APTSS	SPOP	0.9804	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
O60268	Uncharacterized protein KIAA0513	DEG_SPOP_SBC_1	18:22	APTSS	SPOP	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with EIF4G3 mutations

All proteins holding degron of APTSS