DegronMD - O43432(EIF4G3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1172E	TCGA-24-2280	OV	TCGA	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.6744
p.V280A	TCGA-AG-A002	READ	TCGA	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.P274R	TCGA-AP-A0LF	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.P274R	DO43610	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.Q1170E	TCGA-BL-A3JM	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.6744
p.D1168Y	TCGA-BT-A20X	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2778
p.G1188V	TCGA-DK-AA6R	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.0556
p.A429T	TCGA-IB-7651	PAAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1944
p.A429T	DO46657	PAAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1944
p.S279F	TCGA-IB-7651	PAAD	TCGA	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.S279F	DO46657	PAAD	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.P409L	TCGA-VQ-A8PX	STAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.0833
p.P409L	DO51778	STAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.0833
p.P427S	TCGA-Z2-AA3S	SKCM	TCGA	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.P427S	DO51302	SKCM	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.P427S	ACH-000987	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.P427S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.A410D	TCGA-ZG-A9L5	PRAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.A410D	DO219422	PRAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.E1162K	DO44045	BLCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.1111
p.I1164V	DO791	BLCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.1667
p.T1181A	DO8264	COAD	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.25
p.T1181A	DO52402	UCEC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.25
p.M1177T	DO222864	COCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.7423
p.R1184S	DO234253	ESAD	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.1667
p.D277E	DO229018	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.S295R	DO229026	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0556
p.P271T	DO229026	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0556
p.G413V	DO25396	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1944
p.G413D	DO45340	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1944
p.L417F	DO23557	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.3056
p.P1180R	DO26553	LUSC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2778
p.V417A	DO228447	MALY	ICGC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.3056
p.F272L	DO222847	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.F272L	DO48547	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.P288L	DO227740	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.V284M	DO48946	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7208
p.F1182L	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2222
p.A1170S	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.7588
p.E1174G	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.7199
p.L281I	DO42033	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7174
p.A286T	DO41235	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.E1174K	DO42472	UCEC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation altering degron motif	0.7022
p.P420L	SIDM00545	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7582
p.P420L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7582
p.P420S	SIDM00545	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.6752
p.P420S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.6752
p.I278V	SIDM00845	Burkitt's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.F1187S	SIDM00795	Melanoma	GDSC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.0833
p.F1187S	A375	skin	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.0833
p.R275Q	SIDM00217	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.R275Q	SNU-1040	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.G1166E	SIDM00312	Plasma Cell Myeloma	GDSC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2222
p.G1166E	L-363	haematopoietic and lymphoid tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2222
p.D1168V	ACH-000124	Lymphoma	CCLE	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2778
p.D1168V	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.2778
p.P415L	ACH-000170	Non-Cancerous	CCLE	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.P427L	ACH-000987	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.P427L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.R412S	KYSE-220	oesophagus	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1667
p.D1162V	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	1170:1178	Mutation rewiring degron network	0.1111
p.E289Q	NCI-H1838	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.N418T	KNS-62	lung	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7055
p.T418P	DOV13	ovary	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7031
p.P421L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7582
p.R287Q	SNU-1040	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.A286V	PL18	pancreas	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.R282Q	SNU-1040	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7329
p.P432L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.P432S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.E292D	TK	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.T413P	DOV13	ovary	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1944
p.P409S	SW962	vulva	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.0833
p.P421S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.6752
p.P291S	TE-441-T	soft tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.R276Q	SNU-1040	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF4G3

UniProt ID: O43432

Entrez ID: 8672

Protein name: Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF4G3 in