DegronMD

Uniprot ID: O43432

Source protein: Eukaryotic translation initiation factor 4 gamma 3

Source gene: EIF4G3

Class: DEG_APCC_DBOX_1

Location: 1170:1178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.628

ASA_SCORE: 106.0889

COIL: 0.2041

CONS_SCORE: 0.2477

DSS_SCORE: 0.6367

HELIX: 0.7902

FCONS_SCORE: 1.0466

RIG_SCORE: 0.7571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1172E	TCGA-24-2280	OV	TCGA	RREMLETVK	DEG_APCC_DBOX_1	0.6744
p.Q1170E	TCGA-BL-A3JM	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	0.6744
p.D1168Y	TCGA-BT-A20X	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	0.2778
p.G1188V	TCGA-DK-AA6R	BLCA	TCGA	RREMLETVK	DEG_APCC_DBOX_1	0.0556
p.E1162K	DO44045	BLCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.1111
p.I1164V	DO791	BLCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.1667
p.T1181A	DO8264	COAD	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.25
p.T1181A	DO52402	UCEC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.25
p.M1177T	DO222864	COCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.7423
p.R1184S	DO234253	ESAD	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.1667
p.P1180R	DO26553	LUSC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.2778
p.F1182L	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.2222
p.A1170S	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.7588
p.E1174G	DO229275	THCA	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.7199
p.E1174K	DO42472	UCEC	ICGC	RREMLETVK	DEG_APCC_DBOX_1	0.7022
p.F1187S	SIDM00795	Melanoma	GDSC	RREMLETVK	DEG_APCC_DBOX_1	0.0833
p.F1187S	A375	skin	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	0.0833
p.G1166E	SIDM00312	Plasma Cell Myeloma	GDSC	RREMLETVK	DEG_APCC_DBOX_1	0.2222
p.G1166E	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	0.2222
p.D1168V	ACH-000124	Lymphoma	CCLE	RREMLETVK	DEG_APCC_DBOX_1	0.2778
p.D1168V	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	0.2778
p.D1162V	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	RREMLETVK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_APCC_DBOX_1	1170:1178	RREMLETVK	APC,CDC20,FZR1	0.628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons