DegronMD

Uniprot ID: O43432

Source protein: Eukaryotic translation initiation factor 4 gamma 3

Source gene: EIF4G3

Class: DEG_SCF_FBW7_1

Location: 418:424

E3 ligase: FBXW7

DEGRON score: 0.939

ASA_SCORE: 98.4429

COIL: 0.9829

CONS_SCORE: 0.2749

DSS_SCORE: 0.6439

HELIX: 0.0074

FCONS_SCORE: 1.0886

RIG_SCORE: 0.5116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A429T	TCGA-IB-7651	PAAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A429T	DO46657	PAAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.P409L	TCGA-VQ-A8PX	STAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.0833
p.P409L	DO51778	STAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.0833
p.P427S	TCGA-Z2-AA3S	SKCM	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.P427S	DO51302	SKCM	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.P427S	ACH-000987	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.P427S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.A410D	TCGA-ZG-A9L5	PRAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.1111
p.A410D	DO219422	PRAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1111
p.G413V	DO25396	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.G413D	DO45340	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.L417F	DO23557	LUAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.3056
p.V417A	DO228447	MALY	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.3056
p.P420L	SIDM00545	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.7582
p.P420L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.7582
p.P420S	SIDM00545	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.6752
p.P420S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.6752
p.P415L	ACH-000170	Non-Cancerous	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.P427L	ACH-000987	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.P427L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.R412S	KYSE-220	oesophagus	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.1667
p.N418T	KNS-62	lung	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.7055
p.T418P	DOV13	ovary	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.7031
p.P421L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.7582
p.P432L	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.1111
p.P432S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.1111
p.T413P	DOV13	ovary	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.P409S	SW962	vulva	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.0833
p.P421S	Mewo	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SCF_FBW7_1	418:424	PPTPPAS	FBXW7	0.939	More...
Q8IZN3	Palmitoyltransferase ZDHHC14	DEG_SCF_FBW7_1	408:414	PPTPPAS	FBXW7	0.9991	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	3897:3903	PPTPPAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPPAS

Degron related mutations and impact score

Drug responses associated with EIF4G3 mutations

All proteins holding degron of PPTPPAS