DegronMD - Q8IZN3(ZDHHC14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A413T	TCGA-EJ-A46I	PRAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation altering degron motif	0.6028
p.A413T	DO48544	PRAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation altering degron motif	0.6028
p.A402S	TCGA-O2-A52N	LUSC	TCGA	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.6477
p.A402S	DO219217	LUSC	ICGC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.6477
p.T422M	DO222946	BTCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation blocking phosphorylation signal	0.5556
p.A424V	DO232761	PBCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.0556
p.T405K	DO229218	THCA	ICGC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2778
p.T405K	DO229218	THCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.25
p.A419T	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM01265	Plasma Cell Myeloma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM01137	Pancreatic Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM00987	Thyroid Gland Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM00722	Mesothelioma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM00043	Head and Neck Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM00149	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.A419T	SIDM01743	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1944
p.D387E	SIDM00845	Burkitt's Lymphoma	GDSC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.0556
p.A421V	SIDM00516	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1389
p.A421V	ACH-002166	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1389
p.A421V	MZ7-mel	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.1389
p.G393W	SIDM00217	Colorectal Carcinoma	GDSC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.G393W	ACH-000999	Colon/Colorectal Cancer	CCLE	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.G393W	SNU-1040	large intestine	COSMIC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.P411L	SIDM00628	Breast Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation altering degron motif	0.7582
p.P411L	ACH-000849	Breast Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation altering degron motif	0.7582
p.A406V	MZ7-mel	skin	COSMIC	LGTPCAS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.25
p.A406V	MZ7-mel	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	408:414	Mutation rewiring degron network	0.2778

Kaplan plot for ZDHHC14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZDHHC14

UniProt ID: Q8IZN3

Entrez ID: 79683

Protein name: Palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZDHHC14 in