DegronMD

Uniprot ID: Q8IZN3

Source protein: Palmitoyltransferase ZDHHC14

Source gene: ZDHHC14

Class: DEG_SCF_FBW7_1

Location: 408:414

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 82.2571

COIL: 0.9581

CONS_SCORE: 0.3319

DSS_SCORE: 0.6071

HELIX: 0.0267

FCONS_SCORE: 1.0865

RIG_SCORE: 0.6156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A413T	TCGA-EJ-A46I	PRAD	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.6028
p.A413T	DO48544	PRAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.6028
p.T422M	DO222946	BTCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.5556
p.A424V	DO232761	PBCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.0556
p.T405K	DO229218	THCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.25
p.A419T	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM01265	Plasma Cell Myeloma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM01137	Pancreatic Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM00987	Thyroid Gland Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM00722	Mesothelioma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM00043	Head and Neck Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM00149	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A419T	SIDM01743	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1944
p.A421V	SIDM00516	Melanoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.1389
p.A421V	ACH-002166	Skin Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.1389
p.A421V	MZ7-mel	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.1389
p.P411L	SIDM00628	Breast Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.7582
p.P411L	ACH-000849	Breast Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.7582
p.A406V	MZ7-mel	skin	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SCF_FBW7_1	418:424	PPTPPAS	FBXW7	0.939	More...
Q8IZN3	Palmitoyltransferase ZDHHC14	DEG_SCF_FBW7_1	408:414	PPTPPAS	FBXW7	0.9991	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	3897:3903	PPTPPAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons