DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_1

Location: 3897:3903

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 70.5

COIL: 0.9543

CONS_SCORE: 0.4368

DSS_SCORE: 0.8186

HELIX: 0.0173

FCONS_SCORE: 1.0634

RIG_SCORE: 0.5475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3898A	TCGA-2F-A9KO	BLCA	TCGA	PPTPPAS	DEG_SCF_FBW7_1	0.6392
p.M3900I	DO52646	BOCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.7618
p.L3897F	DO9796	COAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.6981
p.P3898H	DO229028	LICA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.6583
p.A3909V	DO36388	READ	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1667
p.H3910R	DO37495	SKCM	ICGC	PPTPPAS	DEG_SCF_FBW7_1	0.1389
p.S3903F	SIDM00150	Colorectal Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	0.7982
p.S3903F	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.7982
p.S3903F	KM12	large_intestine	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	0.7982
p.A3902G	ACH-000649	Kidney Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SCF_FBW7_1	418:424	PPTPPAS	FBXW7	0.939	More...
Q8IZN3	Palmitoyltransferase ZDHHC14	DEG_SCF_FBW7_1	408:414	PPTPPAS	FBXW7	0.9991	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	3897:3903	PPTPPAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons