DegronMD

Uniprot ID: Q8IZN3

Source protein: Palmitoyltransferase ZDHHC14

Source gene: ZDHHC14

Class: DEG_SCF_FBW7_1

Location: 397:403

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 70.7714

COIL: 0.8639

CONS_SCORE: 0.3007

DSS_SCORE: 0.5872

HELIX: 0.076

FCONS_SCORE: 0.9464

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A402S	TCGA-O2-A52N	LUSC	TCGA	LGTPCAS	DEG_SCF_FBW7_1	0.6477
p.A402S	DO219217	LUSC	ICGC	LGTPCAS	DEG_SCF_FBW7_1	0.6477
p.T405K	DO229218	THCA	ICGC	LGTPCAS	DEG_SCF_FBW7_1	0.2778
p.D387E	SIDM00845	Burkitt's Lymphoma	GDSC	LGTPCAS	DEG_SCF_FBW7_1	0.0556
p.G393W	SIDM00217	Colorectal Carcinoma	GDSC	LGTPCAS	DEG_SCF_FBW7_1	0.2222
p.G393W	ACH-000999	Colon/Colorectal Cancer	CCLE	LGTPCAS	DEG_SCF_FBW7_1	0.2222
p.G393W	SNU-1040	large_intestine	COSMIC	LGTPCAS	DEG_SCF_FBW7_1	0.2222
p.A406V	MZ7-mel	skin	COSMIC	LGTPCAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZN3	Palmitoyltransferase ZDHHC14	DEG_SCF_FBW7_1	397:403	LGTPCAS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons