DegronMD - Q9Y5B0(CTDP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R787L	TCGA-21-5786	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.R787L	DO26830	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.P528H	TCGA-25-2397	OV	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.0833
p.P528H	DO28265	OV	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.0833
p.T784M	TCGA-59-2349	OV	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.T784M	DO28621	OV	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.T784M	SIDM00500	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.T784M	ACH-000959	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.T784M	ACH-002669	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.R787W	TCGA-59-2349	OV	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.R787W	TCGA-AP-A051	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.R787W	DO28621	OV	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.R787W	DO42673	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.P789L	TCGA-69-7980	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.P789L	DO23678	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.R538L	TCGA-98-8021	LUSC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8428
p.R538L	DO27468	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8428
p.R538W	TCGA-A5-A1OF	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.R538W	TCGA-AX-A2HD	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.R538W	DO42608	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.R538W	DO42568	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.Q426H	TCGA-AP-A1DK	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.Q426H	TCGA-FI-A2F4	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.Q426H	DO43434	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.Q426H	DO42033	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.G545S	TCGA-BG-A222	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5882
p.G545S	DO42977	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5882
p.A786V	TCGA-BP-4988	KIRC	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.A786V	DO17542	KIRC	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.G540A	TCGA-BR-4184	STAD	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.6429
p.G540A	DO38328	STAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.6429
p.A549T	TCGA-BR-8361	STAD	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.2222
p.A549T	DO48032	STAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.2222
p.P413T	TCGA-D3-A5GU	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.5919
p.P413T	DO47584	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.5919
p.P413L	TCGA-D3-A5GU	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.6471
p.P413L	DO47584	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.6471
p.Q417P	TCGA-DK-A1A3	BLCA	TCGA	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.Q417P	DO558	BLCA	ICGC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.A554V	TCGA-EY-A549	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.0833
p.A554V	DO48174	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.0833
p.R799C	TCGA-F1-A448	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.R799C	DO48044	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.E537D	TCGA-OL-A6VQ	BRCA	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5647
p.E537D	DO51214	BRCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5647
p.D550N	DO225153	BRCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1944
p.D550N	DO234202	ESAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1944
p.D550N	DO228138	PBCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1944
p.G532E	DO233158	GACA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1944
p.I798T	DO16999	KIRC	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.R538P	DO230961	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7512
p.R538P	DO224594	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7512
p.I782M	DO231284	PACA	ICGC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0833
p.R787Q	SIDM02021	Esophageal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.D402N	SIDM00422	Hodgkin's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.D402N	ACH-001203	Lymphoma	CCLE	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.D402N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.E418Q	SIDM01048	Plasma Cell Myeloma	GDSC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.E418Q	SIDM00367	Small Cell Lung Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.E418Q	ACH-000821	Myeloma	CCLE	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.E418Q	ACH-002197	Lung Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.E418Q	SBC-3	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.E418Q	EJM	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2778
p.W407R	SIDM00042	Pancreatic Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1944
p.E534D	SIDM00210	Ovarian Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.25
p.E534D	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.25
p.R538Q	SIDM00223	Small Cell Lung Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7329
p.R538Q	ACH-002144	Lung Cancer	CCLE	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7329
p.R538Q	IST-SL1	lung	COSMIC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7329
p.P792S	SIDM00640	Mesothelioma	GDSC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.5641
p.P792S	MSTO-211H	pleura	COSMIC	APSSS	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.5641
p.Q411H	SIDM00220	Ovarian Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.Q411H	ACH-000962	Ovarian Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.Q411H	ACH-001145	Ovarian Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.Q411H	OC-314	ovary	COSMIC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.G543S	SIDM01664	Prostate Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5882
p.G543S	ACH-000952	Prostate Cancer	CCLE	ERDGLCGLG	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5882
p.P797S	ACH-001430	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.E801K	ACH-002055	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1667
p.R419Q	IST-SL1	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTDP1

UniProt ID: Q9Y5B0

Entrez ID: 9150

Protein name: RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTDP1 in