DegronMD

Uniprot ID: Q9Y5B0

Source protein: RNA polymerase II subunit A C-terminal domain phosphatase

Source gene: CTDP1

Class: DEG_APCC_DBOX_1

Location: 537:545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5648

ASA_SCORE: 83.3

COIL: 0.7683

CONS_SCORE: 0.2346

DSS_SCORE: 0.6068

HELIX: 0.1607

FCONS_SCORE: 1.0189

RIG_SCORE: 0.6695

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P528H	TCGA-25-2397	OV	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.0833
p.P528H	DO28265	OV	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.0833
p.R538L	TCGA-98-8021	LUSC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.8428
p.R538L	DO27468	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.8428
p.R538W	TCGA-A5-A1OF	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.8634
p.R538W	TCGA-AX-A2HD	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.8634
p.R538W	DO42608	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.8634
p.R538W	DO42568	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.8634
p.G545S	TCGA-BG-A222	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.5882
p.G545S	DO42977	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.5882
p.G540A	TCGA-BR-4184	STAD	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.6429
p.G540A	DO38328	STAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.6429
p.A549T	TCGA-BR-8361	STAD	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.2222
p.A549T	DO48032	STAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.2222
p.A554V	TCGA-EY-A549	UCEC	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.0833
p.A554V	DO48174	UCEC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.0833
p.E537D	TCGA-OL-A6VQ	BRCA	TCGA	ERDGLCGLG	DEG_APCC_DBOX_1	0.5647
p.E537D	DO51214	BRCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.5647
p.D550N	DO225153	BRCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.1944
p.D550N	DO234202	ESAD	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.1944
p.D550N	DO228138	PBCA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.1944
p.G532E	DO233158	GACA	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.1944
p.R538P	DO230961	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.7512
p.R538P	DO224594	LUSC	ICGC	ERDGLCGLG	DEG_APCC_DBOX_1	0.7512
p.E534D	SIDM00210	Ovarian Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	0.25
p.E534D	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	0.25
p.R538Q	SIDM00223	Small Cell Lung Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	0.7329
p.R538Q	ACH-002144	Lung Cancer	CCLE	ERDGLCGLG	DEG_APCC_DBOX_1	0.7329
p.R538Q	IST-SL1	lung	COSMIC	ERDGLCGLG	DEG_APCC_DBOX_1	0.7329
p.G543S	SIDM01664	Prostate Carcinoma	GDSC	ERDGLCGLG	DEG_APCC_DBOX_1	0.5882
p.G543S	ACH-000952	Prostate Cancer	CCLE	ERDGLCGLG	DEG_APCC_DBOX_1	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDGLCGLG

Degron related mutations and impact score

Drug responses associated with CTDP1 mutations

All proteins holding degron of ERDGLCGLG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_APCC_DBOX_1	537:545	ERDGLCGLG	APC,CDC20,FZR1	0.5648	More...