DegronMD - Q9P0V3(SH3BP4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T33M	TCGA-A5-A0G2	UCEC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.7423
p.T33M	DO41235	UCEC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.7423
p.L193F	TCGA-AP-A0LM	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.L193F	DO43306	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.T203A	TCGA-BR-8361	STAD	TCGA	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.T203A	DO48032	STAD	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.S262L	TCGA-BR-8487	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.7667
p.S262L	TCGA-FI-A2D5	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.7667
p.S262L	DO47867	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.7667
p.S262L	DO41331	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.7667
p.S200T	TCGA-CV-6937	HNSC	TCGA	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.6005
p.S200T	DO14155	HNSC	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.6005
p.E28K	TCGA-DD-AADA	LIHC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.2222
p.E28K	DO52227	LIHC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.2222
p.E28K	SIDM00650	Small Cell Lung Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.2222
p.E28K	SIDM01681	Non-Cancerous	GDSC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.2222
p.E32K	TCGA-DK-A1AB	BLCA	TCGA	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.7022
p.E32K	DO461	BLCA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.7022
p.D258N	TCGA-E2-A1LH	BRCA	TCGA	APTSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.D258N	ACH-001484	Leukemia	CCLE	APTSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.D258N	ACH-001485	Leukemia	CCLE	APTSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.V48I	TCGA-EC-A24G	UCEC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1944
p.V48I	DO40996	UCEC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1944
p.A259V	TCGA-EY-A1GO	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.5825
p.A259V	DO41392	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.5825
p.N50H	TCGA-HZ-A49G	PAAD	TCGA	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1389
p.N50H	DO32811	PAAD	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1389
p.A197T	DO228483	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO230334	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO227999	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO229013	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO229016	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO229003	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO229005	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO234285	ESAD	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.A197T	DO229505	LAML	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.F202S	DO222755	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.S201F	DO229177	LMS	ICGC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7982
p.T267P	DO228236	MALY	ICGC	APTSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.2222
p.P43S	DO220899	MELA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.6752
p.P53R	DO221547	PACA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.0556
p.V252I	SIDM00463	T-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1389
p.N50K	SIDM01186	Breast Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1389
p.N50K	UACC-893	breast	COSMIC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation rewiring degron network	0.1389
p.T33R	SIDM01504	Small Cell Lung Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	32:43	Mutation altering degron motif	0.7876
p.T203P	ACH-000914	Lymphoma	CCLE	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.T203P	HT	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778

Kaplan plot for SH3BP4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3BP4

UniProt ID: Q9P0V3

Entrez ID: 23677

Protein name: SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SH3BP4 in