DegronMD

Uniprot ID: Q9P0V3

Source protein: SH3 domain-binding protein 4

Source gene: SH3BP4

Class: DEG_COP1_1

Location: 32:43

E3 ligase: COP1

DEGRON score: 0.989

ASA_SCORE: 84.1667

COIL: 0.8616

CONS_SCORE: 0.5068

DSS_SCORE: 0.3487

HELIX: 0.0852

FCONS_SCORE: 1.0516

RIG_SCORE: 0.75

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T33M	TCGA-A5-A0G2	UCEC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	0.7423
p.T33M	DO41235	UCEC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.7423
p.E28K	TCGA-DD-AADA	LIHC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	0.2222
p.E28K	DO52227	LIHC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.2222
p.E28K	SIDM00650	Small Cell Lung Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	0.2222
p.E28K	SIDM01681	Non-Cancerous	GDSC	ETSFNDIKVPSP	DEG_COP1_1	0.2222
p.E32K	TCGA-DK-A1AB	BLCA	TCGA	ETSFNDIKVPSP	DEG_COP1_1	0.7022
p.E32K	DO461	BLCA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.7022
p.V48I	TCGA-EC-A24G	UCEC	TCGA	ETSFNDIKVPSP	DEG_COP1_1	0.1944
p.V48I	DO40996	UCEC	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.1944
p.N50H	TCGA-HZ-A49G	PAAD	TCGA	ETSFNDIKVPSP	DEG_COP1_1	0.1389
p.N50H	DO32811	PAAD	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.1389
p.P43S	DO220899	MELA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.6752
p.P53R	DO221547	PACA	ICGC	ETSFNDIKVPSP	DEG_COP1_1	0.0556
p.N50K	SIDM01186	Breast Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	0.1389
p.N50K	UACC-893	breast	COSMIC	ETSFNDIKVPSP	DEG_COP1_1	0.1389
p.T33R	SIDM01504	Small Cell Lung Carcinoma	GDSC	ETSFNDIKVPSP	DEG_COP1_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0V3	SH3 domain-binding protein 4	DEG_COP1_1	32:43	ETSFNDIKVPSP	COP1	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons