DegronMD

Uniprot ID: P10275

Source protein: Androgen receptor

Source gene: AR

Class: DEG_SPOP_SBC_1

Location: 217:221

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 69.42

COIL: 0.9168

CONS_SCORE: 0.4024

DSS_SCORE: 0.6054

HELIX: 0.0492

FCONS_SCORE: 1.037

RIG_SCORE: 0.5796

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P218L	DO220877	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	0.6471
p.P218S	DO220877	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	0.5641
p.K222N	TCGA-B5-A0JY	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.K222N	DO43041	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.A211V	TCGA-36-2533	OV	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.A211V	DO32516	OV	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.A211T	TCGA-AA-A01P	COAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.A211T	DO8642	COAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 8 of 8 entries

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Drug responses associated with AR mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	7.6848
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	AZD3514	20.33
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	71.0099
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	13.0344
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	AZD3514	4.8095
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	114.6281
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	6.1747
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	AZD3514	21.3658
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	70.4477
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	16.1827
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	AZD3514	32.1642
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	148.5768
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	4.5387
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	AZD3514	23.9848
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	66.6243
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	9.1072
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	AZD3514	34.4153
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	64.7057
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	11.3736
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	AZD3514	6.1296
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	24.1556
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	13.0587
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	AZD3514	12.8729
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	70.3036
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	AZD3514	85.3921

Showing 1 to 25 of 141 entries

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All proteins holding degron of APTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with AR mutations

All proteins holding degron of APTSS