DegronMD

Uniprot ID: Q96RK0

Source protein: Protein capicua homolog

Source gene: CIC

Class: DEG_SPOP_SBC_1

Location: 331:335

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 67.44

COIL: 0.8788

CONS_SCORE: 0.5406

DSS_SCORE: 0.5386

HELIX: 0.0768

FCONS_SCORE: 1.3818

RIG_SCORE: 0.5904

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S335F	TCGA-GN-A8LK	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	0.9093
p.S335F	DO51259	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	0.9093
p.R333H	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	0.8244
p.S333N	DO232761	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.818
p.A330S	DO229018	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.3056
p.C336R	DO232519	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.3056
p.R340W	TCGA-FI-A2D5	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340W	DO41331	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340W	SIDM00789	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340W	HCT-15	large_intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340Q	DO228138	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340S	ACH-000260	Neuroblastoma	CCLE	PGSSS	DEG_SPOP_SBC_1	0.1944
p.E326K	ACH-000462	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	0.1944
p.R340L	ACH-000870	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	0.1944
p.S325I	DO229036	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.1667
p.L341P	DO51474	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.1667
p.T322I	DO220899	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 17 of 17 entries

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Drug responses associated with CIC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	42:46	PGSSS	SPOP	0.8462	More...
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	DEG_SPOP_SBC_1	404:408	PGSSS	SPOP	0.996	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	227:231	PGSSS	SPOP	0.8856	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	164:168	PGSSS	SPOP	0.9709	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_SPOP_SBC_1	1133:1137	PGSSS	SPOP	0.993	More...
O75077	Disintegrin and metalloproteinase domain-containing protein 23	DEG_SPOP_SBC_1	4:8	PGSSS	SPOP	0.8481	More...
Q9NRI5	Disrupted in schizophrenia 1 protein	DEG_SPOP_SBC_1	299:303	PGSSS	SPOP	0.9967	More...
P18887	DNA repair protein XRCC1	DEG_SPOP_SBC_1	406:410	PGSSS	SPOP	0.9234	More...
Q9H1R2	Dual specificity protein phosphatase 15	DEG_SPOP_SBC_1	249:253	PGSSS	SPOP	0.9904	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	295:299	PGSSS	SPOP	0.5673	More...
Q13191	E3 ubiquitin-protein ligase CBL-B	DEG_SPOP_SBC_1	839:843	PGSSS	SPOP	0.9865	More...
Q8IUD6	E3 ubiquitin-protein ligase RNF135	DEG_SPOP_SBC_1	104:108	PGSSS	SPOP	0.8243	More...
Q9BZY9	E3 ubiquitin-protein ligase TRIM31	DEG_SPOP_SBC_1	336:340	PGSSS	SPOP	0.7851	More...
Q9NY74	Ewing's tumor-associated antigen 1	DEG_SPOP_SBC_1	771:775	PGSSS	SPOP	0.9697	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	2466:2470	PGSSS	SPOP	0.9912	More...
Q8IVH2	Forkhead box protein P4	DEG_SPOP_SBC_1	388:392	PGSSS	SPOP	0.9716	More...
Q5H8C1	FRAS1-related extracellular matrix protein 1	DEG_SPOP_SBC_1	1879:1883	PGSSS	SPOP	0.9462	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SPOP_SBC_1	24:28	PGSSS	SPOP	0.9942	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1122:1126	PGSSS	SPOP	0.9926	More...
Q3KP66	Innate immunity activator protein	DEG_SPOP_SBC_1	470:474	PGSSS	SPOP	0.9877	More...
Q14573	Inositol 1,4,5-trisphosphate receptor type 3	DEG_SPOP_SBC_1	1836:1840	PGSSS	SPOP	0.9834	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	395:399	PGSSS	SPOP	0.9795	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1026:1030	PGSSS	SPOP	0.9956	More...
Q6NY19	KN motif and ankyrin repeat domain-containing protein 3	DEG_SPOP_SBC_1	500:504	PGSSS	SPOP	0.9835	More...
Q71RC2	La-related protein 4	DEG_SPOP_SBC_1	488:492	PGSSS	SPOP	0.9985	More...

Showing 1 to 25 of 63 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSSS

Degron related mutations and impact score

Drug responses associated with CIC mutations

All proteins holding degron of PGSSS