DegronMD - Q71RC2(LARP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E336V	TCGA-21-A5DI	LUSC	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.7693
p.E336V	DO45455	LUSC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.7693
p.L339P	TCGA-A4-8311	KIRP	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.25
p.L339P	DO44523	KIRP	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.25
p.G489V	TCGA-AN-A046	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation altering degron motif	0.6421
p.N483K	TCGA-AP-A1DV	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1944
p.S594N	TCGA-AX-A1CE	UCEC	TCGA	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.6111
p.F484V	TCGA-BS-A0UV	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.2222
p.P485S	TCGA-D3-A3CB	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.P341H	TCGA-EE-A2GE	SKCM	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1944
p.P341H	DO38016	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1944
p.P488L	TCGA-EE-A2MP	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation altering degron motif	0.7582
p.S482L	TCGA-EK-A2H0	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1667
p.S591L	TCGA-F5-6814	READ	TCGA	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.6944
p.S591L	ACH-000942	Leukemia	CCLE	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.6944
p.A596V	TCGA-PK-A5HB	ACC	TCGA	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1111
p.V499I	TCGA-S9-A7J3	LGG	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1389
p.D478G	TCGA-WE-A8ZM	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.0556
p.E591D	DO219011	BLCA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.6944
p.R335I	DO1285	BRCA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.8102
p.E595D	DO4599	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.5833
p.E598K	DO4599	BRCA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.P338S	DO51642	CESC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.2778
p.V319G	DO222798	COCA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.0556
p.V590F	DO14790	HNSC	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2778
p.V590F	DO228976	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2778
p.V574L	DO228976	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.W327C	DO229031	LICA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.2778
p.V590I	DO44784	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.2778
p.S589C	DO44672	LICA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.3056
p.S485I	DO26240	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S485R	DO27917	ORCA	ICGC	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S323F	DO37819	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1667
p.S323F	DO47700	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1667
p.N583Y	DO38887	STAD	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.75
p.P577T	DO229272	THCA	ICGC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.1389
p.N336H	DO43202	UCEC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.7423
p.Y340S	SIDM00255	Neuroblastoma	GDSC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.2222
p.Y340S	NB17	autonomic ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.2222
p.S597L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.5278
p.T595S	ACH-000300	Kidney Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	584:588	Mutation blocking phosphorylation signal	0.5833
p.Y334S	ACH-002282	Neuroblastoma	CCLE	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.6009
p.Y334S	NB17	autonomic ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.6009
p.D496Y	OV-56	ovary	COSMIC	PGSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.2222
p.Y333S	NB17	autonomic ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation altering degron motif	0.712
p.T319A	EB2	haematopoietic and lymphoid tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.0556
p.N344T	Farage	haematopoietic and lymphoid tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1111
p.R341Q	NCI-H2052	pleura	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1944
p.N343T	Farage	haematopoietic and lymphoid tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1389
p.R342Q	NCI-H2052	pleura	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	329:336	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LARP4

UniProt ID: Q71RC2

Entrez ID: 113251

Protein name: La-related protein 4 (La ribonucleoprotein domain family member 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LARP4 in