DegronMD

Uniprot ID: Q71RC2

Source protein: La-related protein 4

Source gene: LARP4

Class: DEG_SCF_FBW7_2

Location: 329:336

E3 ligase: FBXW7

DEGRON score: 0.6025

ASA_SCORE: 70.15

COIL: 0.8563

CONS_SCORE: 0.4381

DSS_SCORE: 0.3399

HELIX: 0.0449

FCONS_SCORE: 0.9581

RIG_SCORE: 0.726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E336V	TCGA-21-A5DI	LUSC	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	0.7693
p.E336V	DO45455	LUSC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.7693
p.L339P	TCGA-A4-8311	KIRP	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	0.25
p.L339P	DO44523	KIRP	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.25
p.P341H	TCGA-EE-A2GE	SKCM	TCGA	PNPTPYFE	DEG_SCF_FBW7_2	0.1944
p.P341H	DO38016	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.1944
p.R335I	DO1285	BRCA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.8102
p.P338S	DO51642	CESC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.2778
p.V319G	DO222798	COCA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.0556
p.W327C	DO229031	LICA	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.2778
p.S323F	DO37819	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.1667
p.S323F	DO47700	SKCM	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.1667
p.N336H	DO43202	UCEC	ICGC	PNPTPYFE	DEG_SCF_FBW7_2	0.7423
p.Y340S	SIDM00255	Neuroblastoma	GDSC	PNPTPYFE	DEG_SCF_FBW7_2	0.2222
p.Y340S	NB17	autonomic_ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.2222
p.Y334S	ACH-002282	Neuroblastoma	CCLE	PNPTPYFE	DEG_SCF_FBW7_2	0.6009
p.Y334S	NB17	autonomic_ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.6009
p.Y333S	NB17	autonomic_ganglia	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.712
p.T319A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.0556
p.N344T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.1111
p.R341Q	NCI-H2052	pleura	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.1944
p.N343T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.1389
p.R342Q	NCI-H2052	pleura	COSMIC	PNPTPYFE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71RC2	La-related protein 4	DEG_SCF_FBW7_2	329:336	PNPTPYFE	FBXW7	0.6025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons