DegronMD - P18887(XRCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L534M	TCGA-A5-A0G2	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.5999
p.L534M	DO41235	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.5999
p.G419S	TCGA-A5-A2K3	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.G419S	DO50408	ESAD	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.G419S	DO43899	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.F542L	TCGA-AX-A0J0	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.25
p.F542L	DO41133	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.25
p.T523M	TCGA-AX-A3G8	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation blocking phosphorylation signal	0.5833
p.T523M	DO41014	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation blocking phosphorylation signal	0.5833
p.Q544R	TCGA-AZ-4615	COAD	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.1944
p.Q544R	DO7977	COAD	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.1944
p.S418N	TCGA-B5-A3FC	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation blocking phosphorylation signal	0.5556
p.S418N	DO41871	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation blocking phosphorylation signal	0.5556
p.P397L	TCGA-BH-A208	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.P397L	TCGA-D5-5537	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.P397L	DO3293	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.P397L	DO8922	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.0833
p.K458E	TCGA-BR-8589	STAD	TCGA	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.3056
p.K458E	DO47813	STAD	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.3056
p.D541Y	TCGA-D3-A2JP	SKCM	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.2778
p.D541Y	DO47407	SKCM	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.2778
p.Q544K	TCGA-GN-A265	SKCM	TCGA	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.1944
p.Q544K	DO37491	SKCM	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.1944
p.H547Y	DO230343	COCA	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.1111
p.Q399R	DO229010	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.Q399R	DO229013	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.Q399R	DO229016	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.Q399R	DO229003	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.Q399R	DO229480	LAML	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.Q399R	DO228947	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.G444E	DO233709	GACA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.1389
p.P451T	DO228952	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation altering degron motif	0.7031
p.P451T	DO229036	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation altering degron motif	0.7031
p.P451H	DO228971	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation altering degron motif	0.7694
p.A442E	DO229015	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.0833
p.A442E	DO229037	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.0833
p.Q441K	DO229037	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.0556
p.P532L	DO220907	MELA	ICGC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.6471
p.D533G	SIDM00534	Colorectal Carcinoma	GDSC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.7198
p.D533G	ACH-000986	Colon/Colorectal Cancer	CCLE	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.7198
p.D533G	ACH-001664	Gastric Cancer	CCLE	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.7198
p.D533G	HT-115	large intestine	COSMIC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation altering degron motif	0.7198
p.S447L	SIDM01205	Acute Myeloid Leukemia	GDSC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6667
p.S447L	SIDM01195	Acute Myeloid Leukemia	GDSC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6667
p.S447L	ACH-000406	Leukemia	CCLE	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6667
p.S447L	ACH-002314	Leukemia	CCLE	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6667
p.S447L	TUR	haematopoietic and lymphoid tissue	COSMIC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6667
p.P448A	SIDM01608	Endometrial Carcinoma	GDSC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.25
p.P448A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation rewiring degron network	0.25
p.S446R	SIDM01435	Hepatocellular Carcinoma	GDSC	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6389
p.S446R	ACH-000686	Liver Cancer	CCLE	PPTPEET	DEG_SCF_FBW7_1	451:457	Mutation blocking phosphorylation signal	0.6389
p.S410N	ACH-000831	Endometrial/Uterine Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation altering degron motif	0.818
p.S416L	TUR	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation blocking phosphorylation signal	0.6111
p.D526E	HMV-II	skin	COSMIC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.2222
p.P398L	CAL-120	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1111
p.R549Q	SNU-1040	large intestine	COSMIC	EPPDLPVPEL	DEG_COP1_1	530:539	Mutation rewiring degron network	0.0556

Kaplan plot for XRCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XRCC1

UniProt ID: P18887

Entrez ID: 7515

Protein name: DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XRCC1 in