DegronMD

Uniprot ID: P18887

Source protein: DNA repair protein XRCC1

Source gene: XRCC1

Class: DEG_COP1_1

Location: 530:539

E3 ligase: COP1

DEGRON score: 0.8922

ASA_SCORE: 83.97

COIL: 0.9276

CONS_SCORE: 0.4195

DSS_SCORE: 0.7926

HELIX: 0.0353

FCONS_SCORE: 0.9499

RIG_SCORE: 0.6686

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D533G	SIDM00534	Colorectal Carcinoma	GDSC	EPPDLPVPEL	DEG_COP1_1	0.7198
p.D533G	ACH-000986	Colon/Colorectal Cancer	CCLE	EPPDLPVPEL	DEG_COP1_1	0.7198
p.D533G	ACH-001664	Gastric Cancer	CCLE	EPPDLPVPEL	DEG_COP1_1	0.7198
p.D533G	HT-115	large_intestine	COSMIC	EPPDLPVPEL	DEG_COP1_1	0.7198
p.P532L	DO220907	MELA	ICGC	EPPDLPVPEL	DEG_COP1_1	0.6471
p.L534M	TCGA-A5-A0G2	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	0.5999
p.L534M	DO41235	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	0.5999
p.T523M	TCGA-AX-A3G8	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	0.5833
p.T523M	DO41014	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	0.5833
p.D541Y	TCGA-D3-A2JP	SKCM	TCGA	EPPDLPVPEL	DEG_COP1_1	0.2778
p.D541Y	DO47407	SKCM	ICGC	EPPDLPVPEL	DEG_COP1_1	0.2778
p.F542L	TCGA-AX-A0J0	UCEC	TCGA	EPPDLPVPEL	DEG_COP1_1	0.25
p.F542L	DO41133	UCEC	ICGC	EPPDLPVPEL	DEG_COP1_1	0.25
p.D526E	HMV-II	skin	COSMIC	EPPDLPVPEL	DEG_COP1_1	0.2222
p.Q544R	TCGA-AZ-4615	COAD	TCGA	EPPDLPVPEL	DEG_COP1_1	0.1944
p.Q544R	DO7977	COAD	ICGC	EPPDLPVPEL	DEG_COP1_1	0.1944
p.Q544K	TCGA-GN-A265	SKCM	TCGA	EPPDLPVPEL	DEG_COP1_1	0.1944
p.Q544K	DO37491	SKCM	ICGC	EPPDLPVPEL	DEG_COP1_1	0.1944
p.H547Y	DO230343	COCA	ICGC	EPPDLPVPEL	DEG_COP1_1	0.1111
p.R549Q	SNU-1040	large_intestine	COSMIC	EPPDLPVPEL	DEG_COP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18887	DNA repair protein XRCC1	DEG_COP1_1	530:539	EPPDLPVPEL	COP1	0.8922	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons