DegronMD

Uniprot ID: P18887

Source protein: DNA repair protein XRCC1

Source gene: XRCC1

Class: DEG_SCF_FBW7_1

Location: 451:457

E3 ligase: FBXW7

DEGRON score: 0.9057

ASA_SCORE: 87.3714

COIL: 0.8131

CONS_SCORE: 0.3728

DSS_SCORE: 0.877

HELIX: 0.1757

FCONS_SCORE: 0.9678

RIG_SCORE: 0.5631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K458E	TCGA-BR-8589	STAD	TCGA	PPTPEET	DEG_SCF_FBW7_1	0.3056
p.K458E	DO47813	STAD	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.3056
p.G444E	DO233709	GACA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.1389
p.P451T	DO228952	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.7031
p.P451T	DO229036	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.7031
p.P451H	DO228971	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.7694
p.A442E	DO229015	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.0833
p.A442E	DO229037	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.0833
p.Q441K	DO229037	LICA	ICGC	PPTPEET	DEG_SCF_FBW7_1	0.0556
p.S447L	SIDM01205	Acute Myeloid Leukemia	GDSC	PPTPEET	DEG_SCF_FBW7_1	0.6667
p.S447L	SIDM01195	Acute Myeloid Leukemia	GDSC	PPTPEET	DEG_SCF_FBW7_1	0.6667
p.S447L	ACH-000406	Leukemia	CCLE	PPTPEET	DEG_SCF_FBW7_1	0.6667
p.S447L	ACH-002314	Leukemia	CCLE	PPTPEET	DEG_SCF_FBW7_1	0.6667
p.S447L	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPEET	DEG_SCF_FBW7_1	0.6667
p.P448A	SIDM01608	Endometrial Carcinoma	GDSC	PPTPEET	DEG_SCF_FBW7_1	0.25
p.P448A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTPEET	DEG_SCF_FBW7_1	0.25
p.S446R	SIDM01435	Hepatocellular Carcinoma	GDSC	PPTPEET	DEG_SCF_FBW7_1	0.6389
p.S446R	ACH-000686	Liver Cancer	CCLE	PPTPEET	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18887	DNA repair protein XRCC1	DEG_SCF_FBW7_1	451:457	PPTPEET	FBXW7	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons