DegronMD - Q13191(CBLB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D340G	TCGA-17-Z037	LUAD	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1389
p.R325G	TCGA-55-6979	LUAD	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.25
p.R325G	DO24110	LUAD	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.25
p.R844W	TCGA-A5-A0G2	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.3056
p.R829S	TCGA-A5-A1OF	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.0556
p.G323V	TCGA-AG-A01W	READ	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1944
p.G323V	DO36382	READ	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1944
p.R335K	TCGA-B5-A3FA	UCEC	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.2778
p.R335K	DO52402	UCEC	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.2778
p.Q318E	TCGA-B6-A0IK	BRCA	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0556
p.Q318E	TCGA-F5-6810	READ	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0556
p.Q318E	DO1902	BRCA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0556
p.Q318E	DO37291	READ	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0556
p.Y329C	TCGA-CV-5434	HNSC	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.5976
p.Y329C	DO14358	HNSC	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.5976
p.P838H	TCGA-D1-A3DA	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.3056
p.L832F	TCGA-DG-A2KK	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.1389
p.P838L	TCGA-EE-A2GC	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.3056
p.P339L	TCGA-FR-A726	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1667
p.P339L	DO48665	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1667
p.P339T	TCGA-FR-A726	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1667
p.P339T	DO48665	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.1667
p.E326K	TCGA-MV-A51V	BLCA	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.2778
p.E326K	DO474	BLCA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.2778
p.G327R	TCGA-QK-A6VB	HNSC	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.3056
p.G327R	DO219054	HNSC	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.3056
p.Y329F	TCGA-WE-AAA0	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.6417
p.Y329F	DO51294	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.6417
p.L829I	DO222798	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.0556
p.G334A	DO50406	ESAD	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.3056
p.D333Y	DO233697	GACA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.7325
p.L330I	DO228948	LICA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.6063
p.S324R	DO229019	LICA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.2222
p.P833S	DO222753	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.1667
p.P833S	DO50299	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.1667
p.P332L	DO222731	MELA	ICGC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.6471
p.F842S	SIDM00857	Melanoma	GDSC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation altering degron motif	0.7982
p.F842S	G-361	skin	COSMIC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation altering degron motif	0.7982
p.P852S	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.0833
p.P852S	HOP-92	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation rewiring degron network	0.0833
p.T337N	SIDM00217	Colorectal Carcinoma	GDSC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation blocking phosphorylation signal	0.6667
p.T337N	SNU-1040	large intestine	COSMIC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation blocking phosphorylation signal	0.6667
p.F842L	SIDM01679	Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	839:843	Mutation altering degron motif	0.6981
p.L330V	ACH-000776	Brain Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.5654
p.L330V	ONS-76	central nervous system	COSMIC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation altering degron motif	0.5654
p.G327V	ACH-000906	Ovarian Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.3056
p.A319S	ACH-002043	Head and Neck Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0833
p.A319S	Ca9-22	upper aerodigestive tract	COSMIC	FYLYPD	LIG_APCC_ABBA_1	328:333	Mutation rewiring degron network	0.0833

Kaplan plot for CBLB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBLB

UniProt ID: Q13191

Entrez ID: 868

Protein name: E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBLB in