DegronMD

Uniprot ID: Q13191

Source protein: E3 ubiquitin-protein ligase CBL-B

Source gene: CBLB

Class: LIG_APCC_ABBA_1

Location: 328:333

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9196

ASA_SCORE: 43.65

COIL: 0.7003

CONS_SCORE: 0.8485

DSS_SCORE: 0.3522

HELIX: 0.0307

FCONS_SCORE: 1.165

RIG_SCORE: 0.7768

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D340G	TCGA-17-Z037	LUAD	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.1389
p.R325G	TCGA-55-6979	LUAD	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.25
p.R325G	DO24110	LUAD	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.25
p.G323V	TCGA-AG-A01W	READ	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.1944
p.G323V	DO36382	READ	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.1944
p.R335K	TCGA-B5-A3FA	UCEC	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.2778
p.R335K	DO52402	UCEC	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.2778
p.Q318E	TCGA-B6-A0IK	BRCA	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.0556
p.Q318E	TCGA-F5-6810	READ	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.0556
p.Q318E	DO1902	BRCA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.0556
p.Q318E	DO37291	READ	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.0556
p.Y329C	TCGA-CV-5434	HNSC	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.5976
p.Y329C	DO14358	HNSC	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.5976
p.P339L	TCGA-FR-A726	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.1667
p.P339L	DO48665	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.1667
p.P339T	TCGA-FR-A726	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.1667
p.P339T	DO48665	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.1667
p.E326K	TCGA-MV-A51V	BLCA	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.2778
p.E326K	DO474	BLCA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.2778
p.G327R	TCGA-QK-A6VB	HNSC	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G327R	DO219054	HNSC	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.Y329F	TCGA-WE-AAA0	SKCM	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.6417
p.Y329F	DO51294	SKCM	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.6417
p.G334A	DO50406	ESAD	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.D333Y	DO233697	GACA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.7325
p.L330I	DO228948	LICA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.6063
p.S324R	DO229019	LICA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.2222
p.P332L	DO222731	MELA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.6471
p.T337N	SIDM00217	Colorectal Carcinoma	GDSC	FYLYPD	LIG_APCC_ABBA_1	0.6667
p.T337N	SNU-1040	large_intestine	COSMIC	FYLYPD	LIG_APCC_ABBA_1	0.6667
p.L330V	ACH-000776	Brain Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	0.5654
p.L330V	ONS-76	central_nervous_system	COSMIC	FYLYPD	LIG_APCC_ABBA_1	0.5654
p.G327V	ACH-000906	Ovarian Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.A319S	ACH-002043	Head and Neck Cancer	CCLE	FYLYPD	LIG_APCC_ABBA_1	0.0833
p.A319S	Ca9-22	upper_aerodigestive_tract	COSMIC	FYLYPD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13191	E3 ubiquitin-protein ligase CBL-B	LIG_APCC_ABBA_1	328:333	FYLYPD	APC,CDC20,FZR1	0.9196	More...
Q9ULV8	E3 ubiquitin-protein ligase CBL-C	LIG_APCC_ABBA_1	306:311	FYLYPD	APC,CDC20,FZR1	0.7258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FYLYPD

Degron related mutations and impact score

Drug responses associated with CBLB mutations

All proteins holding degron of FYLYPD