DegronMD

Uniprot ID: Q9ULV8

Source protein: E3 ubiquitin-protein ligase CBL-C

Source gene: CBLC

Class: LIG_APCC_ABBA_1

Location: 306:311

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7258

ASA_SCORE: 55

COIL: 0.6468

CONS_SCORE: 0.5785

DSS_SCORE: 0.497

HELIX: 0.0482

FCONS_SCORE: 1.0217

RIG_SCORE: 0.735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G305S	TCGA-AX-A1CE	UCEC	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G305S	DO42280	UCEC	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G305S	SIDM01653	Non-Cancerous	GDSC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G305S	SIDM00207	Glioblastoma	GDSC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G305V	TCGA-DX-A6YV	SARC	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.G305V	DO220011	SARC	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.3056
p.D311N	TCGA-IN-A6RP	STAD	TCGA	FYLYPD	LIG_APCC_ABBA_1	0.6932
p.D311N	DO51741	STAD	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.6932
p.E300G	DO44726	LICA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.1667
p.LE299LK	DO222572	MELA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0
p.L298I	DO232224	PBCA	ICGC	FYLYPD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13191	E3 ubiquitin-protein ligase CBL-B	LIG_APCC_ABBA_1	328:333	FYLYPD	APC,CDC20,FZR1	0.9196	More...
Q9ULV8	E3 ubiquitin-protein ligase CBL-C	LIG_APCC_ABBA_1	306:311	FYLYPD	APC,CDC20,FZR1	0.7258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons