DegronMD - Q6NY19(KANK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A497T	TCGA-4T-AA8H	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.A497T	TCGA-EI-6917	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.A497T	DO51724	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.A497T	DO36881	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.A83T	DO233650	GACA	ICGC	AWTSS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1944
p.G79S	DO233747	GACA	ICGC	AWTSS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.S504L	DO14678	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7667
p.G495C	DO45057	LINC	ICGC	PGSSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.Q184R	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation altering degron motif	0.6218
p.Q184R	SIDM01093	Cervical Carcinoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation altering degron motif	0.6218
p.Q184R	SIDM00365	Small Cell Lung Carcinoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation altering degron motif	0.6218
p.L181Q	BFTC-905	urinary tract	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation altering degron motif	0.7765
p.G166S	S-117	soft tissue	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation rewiring degron network	0.1389
p.L163V	TE-8	oesophagus	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation rewiring degron network	0.0556
p.L187F	WM278	skin	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	173:185	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons