DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
AWTSS
Uniprot ID:
Q6NY19
Source protein:
KN motif and ankyrin repeat domain-containing protein 3
Source gene:
KANK3
Class:
DEG_SPOP_SBC_1
Location:
88:92
E3 ligase:
SPOP
DEGRON score:
0.9992
ASA_SCORE:
67.98
COIL:
0.7296
CONS_SCORE:
0.469
DSS_SCORE:
0.6553
HELIX:
0.1076
FCONS_SCORE:
1.1293
RIG_SCORE:
0.6394
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A83T
DO233650
GACA
ICGC
AWTSS
DEG_SPOP_SBC_1
0.1944
p.G79S
DO233747
GACA
ICGC
AWTSS
DEG_SPOP_SBC_1
0.0833
Drug responses associated with KANK3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AWTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B8ZZ34
Protein shisa-8
DEG_SPOP_SBC_1
327:331
AWTSS
SPOP
0.9837
More...
Q6NY19
KN motif and ankyrin repeat domain-containing protein 3
DEG_SPOP_SBC_1
88:92
AWTSS
SPOP
0.9992
More...