DegronMD

Uniprot ID: Q6NY19

Source protein: KN motif and ankyrin repeat domain-containing protein 3

Source gene: KANK3

Class: DEG_ODPH_VHL_1

Location: 173:185

E3 ligase: VHL

DEGRON score: 0.7849

ASA_SCORE: 76.3154

COIL: 0.6463

CONS_SCORE: 0.41

DSS_SCORE: 0.6485

HELIX: 0.3362

FCONS_SCORE: 0.7941

RIG_SCORE: 0.6199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q184R	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.6218
p.Q184R	SIDM01093	Cervical Carcinoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.6218
p.Q184R	SIDM00365	Small Cell Lung Carcinoma	GDSC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.6218
p.L181Q	BFTC-905	urinary_tract	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.7765
p.G166S	S-117	soft_tissue	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.1389
p.L163V	TE-8	oesophagus	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.0556
p.L187F	WM278	skin	COSMIC	LAPASPGPAQLQL	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NY19	KN motif and ankyrin repeat domain-containing protein 3	DEG_ODPH_VHL_1	173:185	LAPASPGPAQLQL	VHL	0.7849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons