DegronMD - Q14573(ITPR3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1849C	TCGA-06-0209	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.0833
p.R1849C	TCGA-19-5956	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.0833
p.R1849C	DO12520	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.0833
p.R1849C	DO13863	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.0833
p.D1017Y	TCGA-06-5416	GBM	TCGA	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1944
p.D1017Y	DO10880	GBM	ICGC	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1944
p.P899L	TCGA-55-A493	LUAD	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1667
p.P899L	DO26328	LUAD	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1667
p.S877I	TCGA-A5-A0G1	UCEC	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1111
p.S877I	DO42472	UCEC	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1111
p.A900S	TCGA-A5-A0G1	UCEC	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1389
p.A900S	DO42472	UCEC	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1389
p.A1530T	TCGA-AX-A2HC	UCEC	TCGA	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.1944
p.A1530T	DO41572	UCEC	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.1944
p.A1831V	TCGA-BR-8360	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1944
p.A1831V	DO47745	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1944
p.M901L	TCGA-DK-A1AA	BLCA	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1111
p.M901L	DO548	BLCA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1111
p.E1000V	DO49324	ALL	ICGC	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1667
p.P899T	DO222755	COCA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation rewiring degron network	0.1667
p.R1829H	DO222737	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1389
p.R1850Q	DO229003	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.0556
p.R1841H	DO50315	ESAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.3056
p.S1550L	DO228641	GACA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.1389
p.S1843L	DO233947	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation blocking phosphorylation signal	0.6944
p.R886L	DO229015	LICA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.8428
p.A1831S	DO229028	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1944
p.C1525F	DO229045	LICA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.0556
p.E1000A	DO228619	PRAD	ICGC	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1667
p.A1546V	DO229250	THCA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.25
p.T885A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.6028
p.T885A	ACH-000914	Lymphoma	CCLE	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.6028
p.T885A	HT	haematopoietic and lymphoid tissue	COSMIC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.6028
p.R886H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.8244
p.R886H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.8244
p.R886H	ACH-000995	Leukemia	CCLE	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.8244
p.R886H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TRTLLGIID	DEG_APCC_DBOX_1	885:893	Mutation altering degron motif	0.8244
p.R1841C	SIDM00197	Ewing's Sarcoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.3056
p.R1841C	SIDM00852	Glioma	GDSC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.3056
p.F998L	SIDM00596	Endometrial Carcinoma	GDSC	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1111
p.F998L	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1111
p.F998L	HEC-1	endometrium	COSMIC	DSGADGT	DEG_SCF_TRCP1_1	1006:1012	Mutation rewiring degron network	0.1111
p.V1830M	SIDM00839	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1667
p.V1830M	LoVo	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1667
p.M1531V	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRAILLPMD	DEG_APCC_DBOX_1	1535:1543	Mutation rewiring degron network	0.2222
p.R1829C	ACH-002026	Endometrial/Uterine Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1836:1840	Mutation rewiring degron network	0.1389

Kaplan plot for ITPR3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITPR3

UniProt ID: Q14573

Entrez ID: 3710

Protein name: Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ITPR3 in