DegronMD

Uniprot ID: Q14573

Source protein: Inositol 1,4,5-trisphosphate receptor type 3

Source gene: ITPR3

Class: DEG_APCC_DBOX_1

Location: 885:893

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5086

ASA_SCORE: 27.5111

COIL: 0.1551

CONS_SCORE: 0.4548

DSS_SCORE: 0.0275

HELIX: 0.8216

FCONS_SCORE: 1.3869

RIG_SCORE: 0.9302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P899L	TCGA-55-A493	LUAD	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	0.1667
p.P899L	DO26328	LUAD	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.1667
p.S877I	TCGA-A5-A0G1	UCEC	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	0.1111
p.S877I	DO42472	UCEC	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.1111
p.A900S	TCGA-A5-A0G1	UCEC	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	0.1389
p.A900S	DO42472	UCEC	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.1389
p.M901L	TCGA-DK-A1AA	BLCA	TCGA	TRTLLGIID	DEG_APCC_DBOX_1	0.1111
p.M901L	DO548	BLCA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.1111
p.P899T	DO222755	COCA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.1667
p.R886L	DO229015	LICA	ICGC	TRTLLGIID	DEG_APCC_DBOX_1	0.8428
p.T885A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	0.6028
p.T885A	ACH-000914	Lymphoma	CCLE	TRTLLGIID	DEG_APCC_DBOX_1	0.6028
p.T885A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	TRTLLGIID	DEG_APCC_DBOX_1	0.6028
p.R886H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	0.8244
p.R886H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TRTLLGIID	DEG_APCC_DBOX_1	0.8244
p.R886H	ACH-000995	Leukemia	CCLE	TRTLLGIID	DEG_APCC_DBOX_1	0.8244
p.R886H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TRTLLGIID	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14573	Inositol 1,4,5-trisphosphate receptor type 3	DEG_APCC_DBOX_1	885:893	TRTLLGIID	APC,CDC20,FZR1	0.5086	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons