DegronMD

Uniprot ID: Q14573

Source protein: Inositol 1,4,5-trisphosphate receptor type 3

Source gene: ITPR3

Class: DEG_SCF_TRCP1_1

Location: 1006:1012

E3 ligase: BTRC

DEGRON score: 0.5055

ASA_SCORE: 73.7

COIL: 0.864

CONS_SCORE: 0.3262

DSS_SCORE: 0.3482

HELIX: 0.1014

FCONS_SCORE: 1.0908

RIG_SCORE: 0.6873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1017Y	TCGA-06-5416	GBM	TCGA	DSGADGT	DEG_SCF_TRCP1_1	0.1944
p.D1017Y	DO10880	GBM	ICGC	DSGADGT	DEG_SCF_TRCP1_1	0.1944
p.E1000V	DO49324	ALL	ICGC	DSGADGT	DEG_SCF_TRCP1_1	0.1667
p.E1000A	DO228619	PRAD	ICGC	DSGADGT	DEG_SCF_TRCP1_1	0.1667
p.F998L	SIDM00596	Endometrial Carcinoma	GDSC	DSGADGT	DEG_SCF_TRCP1_1	0.1111
p.F998L	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGADGT	DEG_SCF_TRCP1_1	0.1111
p.F998L	HEC-1	endometrium	COSMIC	DSGADGT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14573	Inositol 1,4,5-trisphosphate receptor type 3	DEG_SCF_TRCP1_1	1006:1012	DSGADGT	BTRC	0.5055	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons