DegronMD

Uniprot ID: Q14573

Source protein: Inositol 1,4,5-trisphosphate receptor type 3

Source gene: ITPR3

Class: DEG_APCC_DBOX_1

Location: 1535:1543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6925

ASA_SCORE: 66.4667

COIL: 0.6119

CONS_SCORE: 0.3966

DSS_SCORE: 0.091

HELIX: 0.2728

FCONS_SCORE: 1.192

RIG_SCORE: 0.8598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1530T	TCGA-AX-A2HC	UCEC	TCGA	GRAILLPMD	DEG_APCC_DBOX_1	0.1944
p.A1530T	DO41572	UCEC	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	0.1944
p.S1550L	DO228641	GACA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	0.1389
p.C1525F	DO229045	LICA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	0.0556
p.A1546V	DO229250	THCA	ICGC	GRAILLPMD	DEG_APCC_DBOX_1	0.25
p.M1531V	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRAILLPMD	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14573	Inositol 1,4,5-trisphosphate receptor type 3	DEG_APCC_DBOX_1	1535:1543	GRAILLPMD	APC,CDC20,FZR1	0.6925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons