DegronMD - O00750(PIK3C2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D88N	TCGA-A2-A0CL	BRCA	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1667
p.D88N	DO2155	BRCA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1667
p.D77N	TCGA-A5-A0G2	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.5821
p.D77N	DO41235	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.5821
p.R82H	TCGA-AX-A0J1	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7133
p.R82H	TCGA-DF-A2KU	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7133
p.R82H	DO223286	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7133
p.R82H	DO41199	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7133
p.P713S	TCGA-BR-8081	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.2222
p.P713S	DO38795	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.2222
p.R75Q	TCGA-D1-A15X	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	TCGA-FI-A2D5	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	DO43274	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	DO41331	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	SIDM00293	Small Cell Lung Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	ACH-002052	Lung Cancer	CCLE	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	LU-139	lung	COSMIC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R728L	TCGA-DZ-6132	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.R728L	TCGA-EE-A29X	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.R728L	TCGA-GL-6846	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.R728L	DO20808	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.R728L	DO20919	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.R728L	DO37595	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1389
p.G64V	TCGA-EE-A184	SKCM	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0556
p.G64V	DO47442	SKCM	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0556
p.A72E	DO228974	LICA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.2778
p.P71Q	DO229032	LICA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.P89L	DO222749	MELA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1389
p.P715S	DO229459	SKCA	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.2778
p.L709P	DO229234	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1111
p.R75W	SIDM00690	Head and Neck Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM00879	Breast Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM01133	Other Solid Cancers	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM00785	Acute Myeloid Leukemia	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM01409	Bladder Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.P717L	SIDM00032	Bladder Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation altering degron motif	0.7582
p.P717L	SIDM01147	Gastric Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation altering degron motif	0.7582
p.A72V	SIDM00192	Colorectal Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.2778
p.A72V	ACH-000286	Colon/Colorectal Cancer	CCLE	RRTDLKLLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.2778
p.A711V	ACH-000985	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	717:721	Mutation rewiring degron network	0.1667

Kaplan plot for PIK3C2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3C2B

UniProt ID: O00750

Entrez ID: 5287

Protein name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3C2B in