DegronMD

Uniprot ID: O00750

Source protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Source gene: PIK3C2B

Class: DEG_APCC_DBOX_1

Location: 74:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7555

ASA_SCORE: 86.6889

COIL: 0.5721

CONS_SCORE: 0.3097

DSS_SCORE: 0.4853

HELIX: 0.3892

FCONS_SCORE: 0.8933

RIG_SCORE: 0.7767

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D88N	TCGA-A2-A0CL	BRCA	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.1667
p.D88N	DO2155	BRCA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.1667
p.D77N	TCGA-A5-A0G2	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.5821
p.D77N	DO41235	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.5821
p.R82H	TCGA-AX-A0J1	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.7133
p.R82H	TCGA-DF-A2KU	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.7133
p.R82H	DO223286	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7133
p.R82H	DO41199	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7133
p.R75Q	TCGA-D1-A15X	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	TCGA-FI-A2D5	UCEC	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	DO43274	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	DO41331	UCEC	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	SIDM00293	Small Cell Lung Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	ACH-002052	Lung Cancer	CCLE	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.R75Q	LU-139	lung	COSMIC	RRTDLKLLR	DEG_APCC_DBOX_1	0.7329
p.G64V	TCGA-EE-A184	SKCM	TCGA	RRTDLKLLR	DEG_APCC_DBOX_1	0.0556
p.G64V	DO47442	SKCM	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.0556
p.A72E	DO228974	LICA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.2778
p.P71Q	DO229032	LICA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.25
p.P89L	DO222749	MELA	ICGC	RRTDLKLLR	DEG_APCC_DBOX_1	0.1389
p.R75W	SIDM00690	Head and Neck Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM00879	Breast Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM01133	Other Solid Cancers	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM00785	Acute Myeloid Leukemia	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM01409	Bladder Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.8634
p.A72V	SIDM00192	Colorectal Carcinoma	GDSC	RRTDLKLLR	DEG_APCC_DBOX_1	0.2778
p.A72V	ACH-000286	Colon/Colorectal Cancer	CCLE	RRTDLKLLR	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRTDLKLLR

Degron related mutations and impact score

Drug responses associated with PIK3C2B mutations

All proteins holding degron of RRTDLKLLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	DEG_APCC_DBOX_1	74:82	RRTDLKLLR	APC,CDC20,FZR1	0.7555	More...